10/29/2023 0 Comments Vitamin k antidote dose![]() ![]() The urgency of the requirement for reversal should determine the route of administration (ref 2).The intravenous solution can be given orally and a 10mg ampoule diluted to 10ml with Glucose 5% will give a 1mg/ml solution from which the desired dose can then be given as a slow IV push.Intravenous Vitamin K starts to work within six hours and both the oral and intravenous Vitamin K will have completely reversed the effect of warfarin within 24 hours. ![]() Dilute injection to 10 or 20ml Glucose 5% and administer required dose slowly over 3 to 5 minutes (ref 1) - see under "Important information".Konakion MM Paediatric 2mg per 0.2ml ampoule ReconstitutionÄraw up using a 5 micron filter needle Methods of intravenous administration Konakion MM 10mg per 1ml ampoule (usual strength) In cases of major bleeding, a 10mg dose must be given, as anticoagulation should not be required within one week (ref 2).This monograph contains a simplified version of the BNF/BSH guidelines with respect to reversal of anticoagulation as agreed with the consultant haematologist (ref 2).Excessively rapid administration can lead to reactions including flushing, cyanosis, sweating, sense of chest constriction, peripheral vascular collapse.Both the 10mg/1ml and the 2mg/0.2ml preparations are licensed for intravenous injection and oral use.Hypersensitivity reactions have been reported, facilities for treating anaphylaxis must be available.May be administered by registered competent doctor or nurse/midwife Important information ![]()
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